STAYING ACTIVE IS GOOD FOR THE HEART

Before taking ENTRESTO tell your doctor about all of your medical conditions, including if you:

• have a history of hereditary angioedema
• have kidney or liver problems
• are pregnant or plan to become pregnant; are breastfeeding or plan to breastfeed. You should either take ENTRESTO or breastfeed. You should not do both

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take potassium supplements or a salt substitute; nonsteroidal anti-inflammatory drugs (NSAIDs); lithium; or other medicines for high blood pressure or heart problems such as an ACE inhibitor, ARB, or aliskiren.

What are the possible side effects of ENTRESTO?

ENTRESTO may cause serious side effects including:

• Swelling of your face, lips, tongue and throat (angioedema) that may cause trouble breathing and death. Get emergency medical help right away if you have symptoms of angioedema or trouble breathing. Do not take ENTRESTO again if you have had angioedema while taking ENTRESTO
• People who are Black or who have had angioedema and take ENTRESTO may have a higher risk of having angioedema
• low blood pressure (hypotension), which may be more common if you take water pills. Call your doctor if you become dizzy or lightheaded, or you develop extreme fatigue
• kidney problems
• increased amount of potassium in your blood (hyperkalemia)

The most common side effects were low blood pressure, high potassium, cough, dizziness, and kidney problems.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

This information is not comprehensive. Please see full Prescribing Information, including Boxed WARNING, and Patient Prescribing Information.