ABOUT HF THE SYMPTOMS OF HF

What are the symptoms of HF?

With HF, there are many warning signs. But they often go unnoticed. If you think you may be at risk for HF, or if you experience any of the symptoms listed below, let your doctor know right away. If you've been diagnosed with HF, monitor your symptoms with this symptom tracker, and let your doctor know if any new symptoms appear or if any symptom comes back or gets worse.

Click on each symptom to learn more.
Shortness of breath Shortness of breath

People with HF often have trouble breathing during activity as well as when at rest, including when lying down to go to sleep. This is caused by blood backing up and fluid leaking into the lungs.

Shortness of breath
Swelling Swelling

People with HF often complain of having swollen feet, legs, ankles, and even stomachs. This particularly bothersome symptom occurs when blood backs up and fluid collects in the tissues.

Swelling
Fatigue Fatigue

When the heart isn't able to pump out enough blood, the body sends it to the most critical organs first. This means that arm and leg muscles may not receive enough oxygen- and nutrient-rich blood, which can make them feel weaker. As a result, everyday tasks such as walking or climbing stairs can feel exhausting.

Feeling tired, fatigued
Coughing Coughing

A nagging cough, often followed by white or pink mucus, occurs when fluid backs up into the lungs.

Coughing
Confusion or memory loss Confusion or memory loss

When the heart isn't working correctly, the brain may not be getting the blood it needs to function properly. For this reason, people with HF often experience episodes of confusion or memory loss.

Confusion or memory loss
Rapid weight gain Rapid weight gain

Gaining sudden weight—for example, 3 or more pounds in a single day—is generally a sign of fluid retention. If you have HF and notice this symptom, call the doctor right away.

Rapid weight gain

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENTRESTO?

ENTRESTO can harm or cause death to your unborn baby. Talk to your doctor about other ways to treat heart failure if you plan to become pregnant. If you get pregnant while taking ENTRESTO, tell your doctor right away.

INDICATION

What is ENTRESTO?

ENTRESTO is a prescription medicine used to reduce the risk of death and hospitalization in people with certain types of long-lasting (chronic) heart failure. ENTRESTO is usually used with other heart failure therapies, in place of an ACE inhibitor or other ARB therapy.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ENTRESTO?

ENTRESTO can harm or cause death to your unborn baby. Talk to your doctor about other ways to treat heart failure if you plan to become pregnant. If you get pregnant while taking ENTRESTO, tell your doctor right away.

Who should not take ENTRESTO?

Do not take ENTRESTO if you:

  • are allergic to sacubitril or valsartan or any of the ingredients in ENTRESTO
  • have had an allergic reaction including swelling of your face, lips, tongue, throat (angioedema) or trouble breathing while taking a type of medicine called an angiotensin-converting enzyme (ACE) inhibitor or angiotensin II receptor blocker (ARB)
  • take an ACE inhibitor medicine. Do not take ENTRESTO for at least 36 hours before or after you take an ACE inhibitor medicine. Talk with your doctor or pharmacist before taking ENTRESTO if you are not sure if you take an ACE inhibitor medicine
  • have diabetes and take a medicine that contains aliskiren

What should I tell my doctor before taking ENTRESTO?

Before you take ENTRESTO, tell your doctor about all of your medical conditions, including if you have kidney or liver problems; are pregnant or plan to become pregnant; are breastfeeding or plan to breastfeed. You should either take ENTRESTO or breastfeed. You should not do both.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take potassium supplements or a salt substitute; nonsteroidal anti-inflammatory drugs (NSAIDs); lithium; or other medicines for high blood pressure or heart problems such as an ACE inhibitor, ARB, or aliskiren.

What are the possible side effects of ENTRESTO?

ENTRESTO may cause serious side effects including:

  • angioedema that may cause trouble breathing and death. Get emergency medical help right away if you have symptoms of angioedema or trouble breathing. Do not take ENTRESTO again if you have had angioedema while taking ENTRESTO. People who are Black or who have had angioedema and take ENTRESTO may have a higher risk of having angioedema
  • low blood pressure (hypotension). Call your doctor if you become dizzy or lightheaded, or you develop extreme fatigue
  • kidney problems
  • increased amount of potassium in your blood

The most common side effects were low blood pressure, high potassium, cough, dizziness, and kidney problems.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

INDICATION

What is ENTRESTO?

ENTRESTO is a prescription medicine used to reduce the risk of death and hospitalization in people with certain types of long-lasting (chronic) heart failure. ENTRESTO is usually used with other heart failure therapies, in place of an ACE inhibitor or other ARB therapy.

This information is not comprehensive. Please see full Prescribing Information, including Boxed WARNING, and Patient Prescribing Information.

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